Prediction of coding potential (cont.)

• GeneMark (1986)

  • Inhomogeneous Markov chain models
  • Easy trainable (closed solution for Maximum Likelihood)
  • Used extensively in prokaryotic genomes
  • Borodovsky et al. (1993), Computers & Chemistry, 17, 123-133.

• Glimmer (1998)

  • Interpolated Markov chains from first to eighth order
  • Salzberg et al. (1998), NAR, 26(2), 544-548.
  • http://www.tigr.org/softlab/glimmer/glimmer.html

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